D-dimer

[Bred]

D-dimer or is a fibrin degradation product, a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrinogen protein.[1]

D-dimer concentration may be determined by a blood test to help diagnose thrombosis. Since its introduction in the 1990s, it has become an important test performed in patients suspected of thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation.

nastavak -> http://en.wikipedia.org/wiki/D-dimer

Danas je D-dimer postao test izbora u hitnoj dijagnostici pacijenata sa sumnjom na trombozu dubokih vena i pluænu emboliju. D-dimer ima visoku negativnu prediktivnu vrednost i pokazao se kao koristan screening test prve linije ali samo u sluèaju iskljuèivanja TDV kod pacijenata sa niskom ili umerenom PTP. Mora se imati na umu da je D-dimer je marker hiperkoagulabilnosti in vivo ali nije specifièan za trombozu. Poveæane vrednosti D-dimera oèekivane su u svim inflamatornim procesima sa ekstravaskularnim depozitima fibrina,  DIK-u, malignitetu, sepsi, preeklampsiji i td. Razlièiti komercijalni testovi za odreðivanje D-dimera koriste imunolo¹ke metode sa specifiènim monoklonskim antitelima a koriste i razlièite principe merenja (ELISA, laser nefelometrija, turbidimetrija, itd), pa uglavnom imaju visoku osetljivost ali razlièitu, mnogo ni¾u specifiènost. Zato su vrednosti dobijene za D-dimer istog pacijenta razlièitim testovima èesto neuporedive i klinièki neupotrebljive

http://www.flebo.org.rs/poster/Kriterijumi%20za%20primenu%20D-dimera%20u%20dijagnozi%20tromboze%20dubokih%20vena%20-%20Dopsaj%20V..doc


http://www.doiserbia.nbs.bg.ac.yu/ft.aspx?id=0354-950X0304098M

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